Lifestyle and incident dementia: A COSMIC individual participant datameta-analysis.

Stephanie van Asbroeck , Sebastian Köhler (1) , Martin P J van Boxtel (2) , Darren M Lipnicki (3) , John D Crawford (3) , Erico Castro-Costa (4) , Maria Fernanda Lima-Costa (4) , Sergio Luis Blay , Xiao Shifu (5, 6) , Tao Wang (5, 6) , Ling Yue (5, 6) , Richard B Lipton (7, 8, 9) , Mindy J Katz (7, 8, 9) , Carol A Derby (7, 8, 9) , Maëlenn Guerchet (10) , Pierre‐marie Preux (10) , Pascal Mbelesso (11) , Joanna Norton (12) , Karen Ritchie (12) , Ingmar Skoog (13) , Jenna Najar (13) , Therese Rydberg Sterner , Nikolaos Scarmeas (14) , Mary Yannakoulia (15) , Themis Dardiotis (16) , Elena Rolandi (17, 18) , Annalisa Davin (17) , Michele Rossi (17) , Oye Gureje (19) , Akin Ojagbemi (19) , Toyin Bello (19) , Ki Woong Kim (20, 21) , Ji Won Han (20, 21) , Dae Jong Oh (22) , Stella Trompet (23) , Jacobijn Gussekloo (23) , Steffi Riedel-Heller , Susanne Röhr , Alexander Pabst , Suzana Shahar , Nurul Fatin Malek Rivan , Devinder Kaur Ajit Singh , Erin Jacobsen , Mary Ganguli , Tiffany Hughes , Mary Haan , Allison E Aiello , Ding Ding , Qianhua Zhao , Zhenxu Xiao , Kenji Narazaki , Tao Chen , Sanmei Chen , Tze Pin Ng , Xinyi Gwee , Qi Gao , Henry Brodaty , Julian Trollor , Nicole Kochan , Antonio Lobo , Javier Santabárbara , Patricia Gracia-Garcia , Perminder S Sachdev , Kay Deckers

1 MUMC - Maastricht University Medical Centre
2 Department of Psychiatry and Neuropsychology [Maastricht]
3 Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
4 FIOCRUZ - Fundação Oswaldo Cruz / Oswaldo Cruz Foundation
5 Department of Geriatric Psychiatry
6 Shanghai Jiao Tong University [Shanghai]
7 Saul B. Korey Department of Neurology
8 Albert Einstein College of Medicine [New York]
9 Department of Epidemiology and Population Health
10 EpiMaCT - Epidémiologie des Maladies Chroniques en zone tropicale
11 Hôpital de l'Amitié [Bangui]
12 INM - Institut des Neurosciences de Montpellier
13 Sahlgrenska Academy at University of Gothenburg [Göteborg]
14 NKUA - National and Kapodistrian University of Athens
15 Department of Nutrition & Dietetics, Harokopio University, Athens, Greece
16 University Hospital of Larissa
17 Golgi Cenci Foundation
18 Department of Brain and Behavioural Sciences
19 University of Ibadan
20 SNUBH - Seoul National University Bundang Hospital
21 Seoul National University College of Medicine
22 Samsung Medical Center Sungkyunkwan University School of Medicine
23 LUMC - Leiden University Medical Center

Abstract INTRODUCTION The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS We combined data from 21 prospective cohorts across six continents ( N = 31,680) and conducted cohort‐specific Cox proportional hazard regression analyses in a two‐step individual participant data meta‐analysis. RESULTS A one‐standard‐deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow‐up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. Highlights A two‐step individual participant data meta‐analysis was conducted. This was done at a global scale using data from 21 ethno‐regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

Mots clés: age dementia dementia risk reduction education effect modification ethnicity individual participant data meta-analysis interaction lifestyle primary prevention region risk factor risk personalization sex socioeconomic Highlights; age; dementia; dementia risk reduction; education; effect modification; ethnicity; individual participant data meta-analysis; interaction; lifestyle; primary prevention; region; risk factor; risk personalization; sex; socioeconomic Highlights

Domaines: Santé publique et épidémiologie

Stephanie van Asbroeck, Sebastian Köhler, Martin P J van Boxtel, Darren M Lipnicki, John D Crawford, et al.. Lifestyle and incident dementia: A COSMIC individual participant datameta-analysis.. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024, ⟨10.1002/alz.13846⟩. ⟨ird-04562477⟩