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Protein Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

Abstract : Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from silk fibroins make the modular protein highly soluble at physiological pH, a critical requirement for the nanoprecipitation process. With this molecular design, nanocapsules consisting of suckerin-silk fusion protein shells and hexadecane or miglyol cores with sizes in the range 190-250 nm are straightforwardly built.
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https://hal-insa-lyon.archives-ouvertes.fr/hal-03264411
Contributor : Direction de la Recherche Insa Lyon <>
Submitted on : Friday, June 18, 2021 - 11:01:33 AM
Last modification on : Saturday, June 19, 2021 - 4:06:30 AM

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Ricardo Ramos, Kenrick Koh, Bartosz Gabryelczyk, Luxiao Chai, Kanagavel Deepankumar, et al.. Protein Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins. ACS Macro Letters, Washington, D.C : American Chemical Society, 2021, 10 (5), pp.628-634. ⟨10.1021/acsmacrolett.1c00171⟩. ⟨hal-03264411⟩

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